Elp3 modulates neural crest and colorectal cancer migration requiring functional integrity of HAT and SAM domains

Cell migration is a finely tuned biological process that often involves epithelial-mesenchymal transition (EMT). EMT typically characterized by the upregulation of mesenchymal markers such as Snail1. This has been shown to be critical importance normal developmental processes, including neural crest and invasion. Interestingly, similar mechanisms are utilized in disease tumor metastasis migration. Notably, EMT-like processes confer cells with ability migrate, invade, adopt stem cell-like properties largely account for immunosuppression recurrence. Therefore, identifying sensitive may contribute cancer prognosis diagnosis many facets. Previously, we showed Elp3 plays an essential role during stabilizing In current study, further elucidate molecular mechanism underlying colorectal We found mElp3 exerted identical function xElp3 modulating migration, both HAT SAM domains imperative this migratory process. overexpression SW480 promoted cell invasion, stabilized Snail1 requiring integrity domains. Our findings warrant exploration specific target cells.